Scott Lowe

Mathias Heikenwälder

1986 B.S. (Biochemistry & Molecular Biology), University of Wisconsin-Madison
1994 Ph.D. (Biology), Massachusetts Institute of Technology
1995 Postdoc (Dept. of Biology), Massachusetts Institute of Technology

Personal Statement
Our laboratory is interested in understanding how the genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create vulnerabilities that may be targeted therapeutically. Historically our focus has been on studying tumor suppressor genes, particularly in the processes of cell death and senescence, and we have established the importance of these processes in tumor suppression and therapy response. We also explore the genetic requirements for tumor maintenance in order to identify new drug targets. To facilitate our research, we combine genetic and genomic tools that enable us to explore various aspects of cancer biology in a comprehensive way. We also developed fast and flexible non-germline mouse models to rapidly probe gene function in vivo. Using these tools, we recently have produced new insights into p53 action and the consequence of p53 mutations, established the contribution of various tumor suppressor genes in tumor maintenance, and validated new therapeutic targets for a variety of cancers.

Positions and Employment
1995 – 1996 Cold Spring Harbor Fellow, Cold Spring Harbor Laboratory
1996 – 1998 Assistant Investigator, Cold Spring Harbor Laboratory
1998 – 1999 Associate Investigator, Cold Spring Harbor Laboratory
1999 – 2000 Associate Professor, Cold Spring Harbor Laboratory
2000 – 2011 Professor, Cold Spring Harbor Laboratory
2001 – 2011 Deputy Director, Cold Spring Harbor Laboratory Cancer Center
2004 – 2009 Head, James Laboratory, Cold Spring Harbor Laboratory
2005 – pres. Investigator, Howard Hughes Medical Institute
2007 – pres. Program Chair, Cancer and Molecular Biology, Cold Spring Harbor Laboratory
2009 – 2011 Head, Hillside Laboratories, Cold Spring Harbor Laboratory
2011 – pres. Member, Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center
2011 – pres. Professor, Gerstner Sloan-Kettering Graduate School of Biomedical Sciences
2011 – pres. Professor, Weill Cornell Graduate School of Medical Sciences
2011 – pres. Chair, Geoffrey Beene Center for Cancer Research
2012 – pres. Associate Director for Basic Cancer Research, Memorial Sloan Kettering Cancer Center
2014 – pres. Chair, Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center

Other Experience and Professional Memberships (selected)
1995 – pres. Member, American Association for Cancer Research
1999 – 2003 Member, Subcommittee C, NCI
2002 – pres. Cancer Cell, Editorial Board
2005 – 2008 AACR Board of Directors
2014 AACR Annual Meeting, Chair
2016 MSKCC-Nature Symposium, Meeting Organizer

Honors (selected)
2001 AACR Outstanding Investigator Award
2005 Paul Marks Prize for Cancer Research
2006 Fellow, American Association for the Advancement of Science
2013 Alfred G. Knudsen Award, NIH
2013 Fellow, American Academy of Arts and Sciences
2016 Dr. Med. h.c., Goethe University
2017 Member, National Academy of Sciences
2018 AACR G.H.A. Clowes Memorial Award