February 27th, 2019
08:30 a.m. – 10:00 a.m.
10:00 a.m. – 10:30 a.m.
Congress Chair: Lars Zender
AEK Chair: Rainer Engers
10:30 a.m. – 12:30 p.m.
Symposium 1: Cancer Immunology and Immunotherapy I
Chair: Eli Pikarsky (Jerusalem, Israel)
10:30 a.m. – 11:30 a.m. Keynote Lecture:
Ton Schumacher, Netherlands Cancer Institute, Amsterdam, Netherlands:
Regulation of T and myeloid cell activity by immune checkpoints
11:30 a.m. – 12:00 p.m. Oliver Bischof, Institut Pasteur, Paris, France:
Breaking the S-ENesence CODE: Towards Senescence Reversal and Therapeutic Opportunities.
12:00 p.m. – 12:15 p.m. Abstract Short Talk I (Abstract 152) - Amaia Lujambio, New York, USA:
12:15 p.m. – 12:30 p.m. Abstract Short Talk II (Abstract 278) - Mario Bunse, Berlin, Germany:
CAR-T Cells Directed against B cell Surface Antigens for the Targeting of Multiple Myeloma and B Cell Non-Hodgkin’s Lymphoma
12:30 p.m. – 01:30 p.m.
Lunch Break
01:30 p.m. – 03:00 p.m.
Symposium 2: Cancer Immunology and Immunotherapy II
Chair: Ton Schumacher (Amsterdam, Netherlands)
01:30 p.m. – 02:00 p.m. Eli Pikarsky, Institute for Medical Research Israel-Canada (IMRIC), Jerusalem, Israel:
A lymphocyte congress in the liver
02:00 p.m. – 02:30 p.m. Helmut Salih, German Cancer Consortium (DKTK)/ University Hospital Tübingen, Germany:
Translational Immunology: Overcoming barriers in science and bureaucracy
02:30 p.m. – 02:45 p.m. Abstract Short Talk I (Abstract 341) - Adrian Schwarzer, Hannover, Germany:
RNAi-screen identifies mediators of stroma-induced resistance to Notch and mTOR-Inhibition in T-cell acute lymphoblastic leukemia
02:45 p.m. – 03:00 p.m. Abstract Short Talk II (Abstract 102) - Barbara Walch-Rückheim, Homburg/Saar, Germany:
Cervical cancer-instructed stromal fibroblasts enhance IL-23 expression in dendritic cells via an IL-6/C/EBPβ/IL-1β pathway to support Th17 expansion
03:00 p.m. – 03:20 p.m. Poster Flash Talks (2 minutes each Poster)
Chairs: Simone Fulda (Frankfurt/Main, Germany)
Poster Flash Talk (Abstract 0176) - Martin Pfügler, Heidelberg, Germany:
CC-1, A Bispecific PSMA Antibody In An Optimized Format For Treatment Of Prostate Cancer And Squamous Cell Carcinoma Of The Lung
Poster Flash Talk (Abstract 0364) - Johannes Schwenck, Tübingen, Germany:
Distinct metabolic patterns in in vivo F-18 FDG-PET induced by cancer immunotherapy in primary and secondary lymphoid organs
Poster Flash Talk (Abstract 0365) - Josef Leibold, New York, USA:
Dissecting cell autonomous as well as non-cell autonomous differences between stomach cancer subtypes using preclinical mouse models
Poster Flash Talk (Abstract 0135) - Arianna Sabò, Milano, Italy:
An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation
Poster Flash Talk (Abstract 0189) - Giacomo Cossa, Würzburg, Germany:
NUAK1 regulates pre-mRNA splicing through the PPP1R10-PP1-SF3B1 axis in MYC-driven tumors
Poster Flash Talk (Abstract 0035) - Sara Sofia Deville, Dresden, Germany:
Synemin promotes non-homologous end joining through the regulation of c-Abl and DNA-PKcs kinases in head and neck squamous cell carcinomas
Poster Flash Talk (Abstract 0373) - David Yu, Atlanta, GA, USA:
SIRT2 Directs DNA Double-Strand Break Repair Through DNA-PKcs Deacetylation to Govern Radiation Resistance and can be Exploited for Cancer Therapy
Poster Flash Talk (Abstract 0299) - Meike Vogler, Frankfurt/Main, Germany:
Evaluation of the different anti-apoptotic BCL-2 proteins as therapeutic targets in AML
03:20 p.m. – 04:30 p.m.
Coffee break and Poster Session I
04:30 p.m. – 06:30 p.m. Symposium 3: Targeting Myc and Ras
Chair: Johannes Zuber (Vienna, Austria)
04:30 p.m. – 05:00 p.m. Gerard Evan, University of Cambridge, Cambridge, United Kingdom:
How Ras and Myc cooperate to make cancers, and to maintain them
05:00 p.m. – 05:30 p.m. Bruno Amati, European Insitute of Oncology, Milan, Italy:
Pre-clinical and genetic modeling of MYC/BCL2 double-hit lymphoma
05:30 p.m. – 06:00 p.m. Martin Eilers, University of Würzburg, Germany:
Exploiting Insights into MYC Turnover for Tumor Therapy
06:00 p.m. – 06:15 p.m. Abstract Short Talk I (Abstract 146) - Gabriele Büchel, Würzburg, Germany:
Co-ordination of MYCN-driven transcription and DNA replication in neuroblastoma
06:15 p.m. – 06:30 p.m. Abstract Short Talk II (Abstract 371) - Arianna Giacomini, Brescia, Italy:
Inhibition of the Fibroblast Growth Factor system by a new FGF trap induces c-Myc degradation-mediated oxidative stress and apoptosis in multiple myeloma cells
From 06:30 p.m.
Welcome Reception and Awards

February 28th, 2019
09:00 a.m. – 11:00 a.m. Symposium 4: Replicative Stress and DNA Damage Response
Chair: Scott Lowe (New York, USA)
09:00 a.m. – 09:30 a.m. Jos Jonkers, Netherlands Cancer Institute, Amsterdam, Netherlands:
Identification of cancer drivers and mechanisms of therapy resistance in mouse models of BRCA-deficient breast cancer
09:30 a.m. – 10:00 a.m. Matthias Dobbelstein, University of Göttingen, Germany:
Control of DNA replication forks – signaling pathways, chromatin modifications, and p53
10:00 a.m. – 10:30 a.m. Luis Toledo Lazaro, University of Copenhagen, Copenhagen, Denmark:
DNA Polymerase Alpha: an Achilles’ heel of DNA replication to exploit in therapy?
10:30 a.m. – 10:45 a.m. Abstract Short Talk I (Abstract 315) - Nisar Malek, Tübingen, Germany:
p27kip1 regulates DNA double strand repair pathway choice through its interaction with rad17
10:45 a.m. – 11:00 a.m. Abstract Short Talk II (Abstract 76) - Balca Mardin, Heidelberg, Germany:
CAT-R, a high-throughput CRISPR/Cas9 based reporter, to trace DNA repair pathways
11:00 a.m. – 11:30 a.m. Coffee break  
11:30 a.m.  01:30 p.m.
Symposium 5: Cellular Senescence in Cancer
Chair: Michael Karin (San Diego, USA)
11:30 a.m. – 12:00 p.m. René Bernards, Netherlands Cancer Institute, Amsterdam, Netherlands:
Exploiting pro-senescence strategies for cancer therapy
12:00 p.m. – 12:30 p.m. Michael Karin, University of California, San Diego, USA:
Immune Control of Hepatic Tumorigenes
12:30 p.m. – 01:00 p.m. Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne, France:
Expanding roles of cGAS in immunity and inflammation
01:00 p.m. – 01:15 p.m. Abstract Short Talk I (Abstract 415) - Katharina Wolter, Tübingen, Germany:
Therapeutic Induction and Image guided senolytic exploitation of Ribosomal Checkpoint Induced Senescence (RCIS) in Liver Cancer
01:15 p.m. – 01:30 p.m. Abstract Short Talk II (Abstract 148) - Rana Salam, Paris, France:
Cellular senescence acts as a protumoral mechanism during gliomagenesis
01:30 p.m.  02:30 p.m. Lunch break  
02:30 p.m.  04:30 p.m. Symposium 6: Metastasis
Chair: Douglas Hanahan (Lausanne, Switzerland)
02:30 p.m. – 03:30 p.m. Keynote Lecture:
Joan Massagué, Memorial Sloan Kettering Cancer Center, New York, USA:
Regenerative Origin of L1CAM+ Metastasis Initiating Cells
03:30 p.m. – 04:00 p.m. Klaus Pantel, University Hospital Hamburg, Germany:
Liquid Biopsy: Clinical Applications and Current Challenges
04:00 p.m. – 04:15 p.m. Abstract Short Talk I (Abstract 45) - Stefanie Maurer, Tübingen, Germany:
The role of platelet-derived RANKL in metastasis
04:15 p.m. – 04:30 p.m. Abstract Short Talk II (Abstract 204) - Fabian Franke, Munich, Germany:
The tumor suppressor SASH1 interacts with CRK-family proteins to inhibit epithelial-mesenchymal transition and metastasis formation
04:30 p.m. – 04:50 p.m. Poster Flash Talks (2 minutes each Poster)
Chairs: Lars Zender (Tübingen, Germany)
Poster Flash Talk (Abstract 0253) - Dennis Kobelt, Berlin, Germany:
Targeting the novel biomarker MACC1 to restrict cancer metastasis
Poster Flash Talk (Abstract 0068) - Lisa Becker, Heidelberg, Germany:
Exploring therapy response in metastatic breast cancer CTCs by single cell analyses and patient-specific in vitro models
Poster Flash Talk (Abstract 0141) - Daniel Merk, Tübingen, Germany:
A genome-wide CRISPR/Cas9 knockout screen identifies therapeutic targets for Sonic hedgehog medulloblastoma
Poster Flash Talk (Abstract 0150) - Claudia Tonelli, Cold Spring Harbour, USA:
Improved modeling of pancreatic cancer progression using epithelial organoid cultures.
Poster Flash Talk (Abstract 0197) - Michael Cangkrama, Zurich, Switzerland:
A novel activin A–mDia2 axis promotes tumor formation via fibroblast reprogramming
Poster Flash Talk (Abstract 0292) - Maren Pein, Heidelberg, Germany:
Metastasis-initiating cells induce and exploit a fibroblast niche in the lungs to fuel metastatic colonization
Poster Flash Talk (Abstract 0407) - Mahak Singhal, Heidelberg, Germany:
Integrated multi-omics approach identifies LRG1 as a novel angiocrine modulator of metastasis
04:50 p.m. – 05:30 p.m. Coffee break & Poster Session II
05:30 p.m.  06:30 p.m.
AEK Member Assembly
07:30 p.m.
Conference Dinner and Party


March 1st, 2019
09:00 a.m.  11:00 a.m.
Symposium 7: Novel Tools and Model Systems in Cancer Research
Chair: Simone Fulda (Frankfurt/Main, Germany)
09:00 a.m. - 09:30 a.m. Scott Lowe, Memorial Sloan Kettering Cancer Center, New York, USA:
Cancer drivers and dependencies
09:30 a.m. - 10:00 a.m. Michael T. Hemann, Massachussetts Institute of Technology, Cambridge, USA:
Finding New Uses for Old Cancer Drugs
10:00 a.m. - 10:30 a.m. Mathias Heikenwälder, German Cancer Research Center (DKFZ), Heidelberg, Germany:
On distinct immune cells causing liver cancer
10:30 a.m. - 10:45 a.m. Abstract Short Talk I (Abstract 79) - Olaf Klingbeil, Cold Spring Harbor, USA:
Paralog co-targeting using domain focused CRISPR screening uncovers gene redundancy relationships in human cancer models
10:45 a.m. - 11:00 a.m. Abstract Short Talk II (Abstract 377) - Anja Ebert, Vienna, Austria:
Probing direct transcriptional functions using targeted protein degradation and SLAM-seq
11:00 a.m. - 11:30 a.m.
Coffee break
11:30 a.m. - 01:45 p.m. Symposium 8: Tumor Microenvironment
Chair: Lars Zender (Tübingen, Germany)
11:30 a.m. - 12:00 p.m. Douglas Hannahan, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland:
Microenvironmental determinants of invasion and metastasis
12:00 p.m. - 12:30 p.m. Anna Obenauf, IMP Research Institute of Molecular Pathology, Vienna, Austria:
Tumor evolution during cancer progression and therapy
12:30 p.m. - 01:00 p.m. Florian Greten, University of Frankfurt, Frankfurt/Main, Germany:
Cell Plasticity in Colon Carcinogenesis
01:00 p.m. - 01:15 p.m. Abstract Short Talk I (Abstract 134) - Ina Oehme, Heidelberg, Germany:
A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment
01:15 p.m. - 01:30 p.m. Abstract Short Talk II (Abstract 266) - Cathinka Boedicker, Frankfurt/Main, Germany:
Combined inhibition of BET proteins and PI3Kα reallocates BRD4 to transcriptional regulatory elements of BH3-only proteins and induces mitochondrial apoptosis
01:30 p.m. - 01:45 p.m. Abstract Short Talk III (Abstract 394) - Daniel Dauch, Tübingen, Germany:
Liver X receptor mediated lipotoxicity represents a treatment option for liver cancer
01:45 p.m. Farewell Snacks


Subject to change without notice. Last Changes: February 7th, 2019.