Florian Greten

Educational Background:

since 08/2013 Chair of Tumor Biology (W3), Medical Faculty, Goethe University Frankfurt and Scientific Director, Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt

2010 – 2013 Professor of Molecular Gastrointestinal Oncology (W2), Klinikum rechts der Isar, Technical University Munich

07/2008 Habilitation, Internal Medicine, Technical University Munich

08/2005 – 07/2010 Emmy-Noether-Group Leader

07/2004 – 02/2008 Residency, 2nd Dept. of Medicine, Klinikum rechts der Isar, Technical University Munich

01/2001 – 06/2004 Postdoctoral Fellowship with Professor Michael Karin, Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, U.S.A.

06/1998 – 12/2000 Internship and Residency, Dept. of Internal Medicine, University Hospital Ulm

06/1998 Medical Degree, University Hamburg

10/1991 – 04/1998 Medical School, University Hamburg and University of Vienna

Awards and Honors:

2015 Member of “Hinterzartener Kreis der DFG für Krebsforschung”
2014 Innovation Award for Life Sciences, Goethe-University Frankfurt
2013 Wilhelm-Vaillant Award
2012 German Cancer Award
2011 ERC Starting Grant
2010 AIO Scientific Award of the German Cancer Society
2010 Dr. Emil Salzer Award for Cancer Research of the German Cancer Research Center (DKFZ)
2010 Theodor-Frerichs-Award of the German Society of Internal Medicine
2010 Johann-Georg-Zimmermann Award for Cancer Research
2009 European Association for Cancer Research (EACR) Research Award Lecture
2007 Pro Scientia Award of the Eckhart-Buddecke-Foundation
2006 “Rising Star”, Association of National European and Mediterranean Societies of Gastroenterology (ASNEMGE)
2005 Emmy-Noether Research Group

Specialty and Present Interest

Tumor Microenvironment, Colon Cancer, Cancer Stem Cells

Selected publications

1. Ziegler, PK, Bollrath, J, Pallangyo, CK, Matsutani, T, Canli, Ö, DeOliveira, T, Diamanti, MA, Müller, N, Gamrekelashvili, Putoczki, T, Horst, D, Mankan, AK, Öner, MG, Müller, S, Müller-Höcker, J, Kirchner, T, Slotta-Huspenina, J, Taketo, MM, Reinheckel, T, Dröse, S, Larner, AC, Wels, WS, Ernst, M, Greten, TF, Arkan, MC, Korn, T, Wirth, D, Greten, FR.: Mitophagy in intestinal epithelial cells triggers adaptive immunity during tumorgenesis. Cell. 2018 Jun 28;174(1):88-101
2. Varga, J., Greten FR.: Cell Plasticity in Epithelial Homeostasis and Tumorigenesis. Nat Cell Biol. 2017, 19:1133-1141
3. Canli Ö, Adele M Nicolas, Gupta J, Finkelmeier F, Olga Goncharova, Pesic M, Tobias Neumann, Horst D, Löwer M, Sahin U, Greten FR. Myeloid cell-derived reactive oxygen species induce epithelial mutagenesis. Cancer Cell, 2017, 32:869-883.
4. Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Hejimans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, Lang R, Neumann, J, Kirchner T, Taketo MM, van den Brink GR, Sansom OJ, Arkan MC, and Greten FR. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell like properties. Cell 2013; 152:25-38.
5. Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, and Greten FR. Loss of p54 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. Cancer Cell 2013; 23:93-106.