Bruno Amati

Bruno Amati


Department of Experimental Oncology
European Institute of Oncology (IEO)
Via Adamello 16, Milan 20139, Italy.

Phone: +39 02 57489824 (off.); +39 335 153 9289 (cell);
Fax: +39 02 57489851

Academic education

1981-1985 Undergraduate studies in Biology, University of Geneva, Switzerland
1985 Diploma in Biology, University of Geneva
1986 Certificate of specialization in Molecular Biology (equiv. Masters), University of Geneva
1990 Ph.D., Swiss Institute for Experimental Cancer Research (ISREC) and Univ. of Lausanne, Switzerland

Positions Held

1984/85 Internship, c/o Prof. U.K. Laemmli, Dept. of Molecular Biology, University of Geneva
1985/86 Internship, c/o Prof. Jean-David Rochaix, Dept. of Molecular Biology, University of Geneva
1986-1990 Ph.D. student, c/o Dr. S.M. Gasser, ISREC, Lausanne
1990-1993 Post-doc c/o Dr. H. Land, Imperial Cancer Research Fund (ICRF), London
1994-1999 Associate Scientist (junior group leader) at ISREC, as recipient of a START fellowship from the Swiss National Science Foundation
1999-2002 Research Fellow (senior group leader) at DNAX, Palo Alto (CA)
2003-present Division Director (senior group leader, tenured), IEO, Milan
2011-2017 Joint appointment with the Italian Institute of Technology (IIT) as founding Director of its Milan outstation, the Center for Genomic Science of IIT@SEMM
July 2018-present Scientific Director, European School of Molecular Medicine (SEMM;

Publications (last 5 years; *corresponding Author)

1. Campaner S, Viale A, De Fazio S, Doni M, De Franco F, D'Artista L, Sardella D, Pelicci PG, Amati B. A non-redundant function of cyclin E1 in Hematopoietic Stem Cells. Cell Cycle 12, 3663-3672 (2013); DOI: 4161/cc.26584
2. Sabò A, Amati B*. Genome recognition by Myc. Cold Spring Harb Perspect Biol. 4:a014191 (2014) [review]; DOI: 1101/cshperspect.a014191
3. Sabò A, Doni M, Amati B*. SUMOylation of Myc-family proteins. PLoS ONE 9, e91072 (2014); DOI: 1371/journal.pone.0091072
4. Almouzni G, Altucci L, Amati B, Ashley N, ... (57 other authors). Relationship between genome and epigenome - challenges and requirements for future research. BMC Genomics 15, 487 (2014); DOI: 1186/1471-2164-15-487
5. Sabò A, Kress TR, Pelizzola M, de Pretis S, Gorski MM, Tesi A, Morelli MJ, Bora P, Doni M, Verrecchia A, Tonelli C, Fagà G, Bianchi V, Ronchi A, Low D, Müller H, Guccione E, Campaner S, Amati B*. Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature 511, 488-492 (2014); DOI: 1038/nature13537
6. Pelizzola M*, Morelli MJ, Sabò A, Kress TR, de Pretis S, Amati B*. Selective transcriptional regulation by Myc: experimental design and computational analysis of high-throughput sequencing data. Data in Brief 3, 40-46 (2015); DOI: 1016/j.dib.2015.02.003
7. de Pretis S, Kress TR, Morelli MJ, Melloni GEM, Riva L, Amati B, Pelizzola M. INSPEcT: a Computational Tool to Infer mRNA Synthesis, Processing and Degradation Dynamics from RNA- and 4sU-seq Time Course Experiments. Bioinformatics 31, 2829-2835 (2015); DOI: 1093/bioinformatics/btv288
8. Koh CM, Bezzi M, Low DHP, Ang WX, Teo SX, Gay FPH, Al-Haddawi M, Tan SY, Osato M, Sabò A, Amati B, Wee KB, Guccione E. MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis. Nature 523, 96-100 (2015); DOI: 1038/nature14351
9. Tonelli C, Morelli MJ, Bianchi S, Rotta L, Capra T, Sabò A, Campaner S, Amati B*. Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo. Oncotarget 6, 24611-24626 (2015); DOI: 10.18632/oncotarget.5232
10. Kress TR, Sabò A, Amati B*. Myc: connecting selective transcriptional control to global RNA production. Nature Reviews Cancer 15, 593-607 (2015); DOI:10.1038/nrc3984
11. Kishore K, de Pretis S, Lister R, Morelli MJ, Bianchi V, Amati B, Ecker JR, Pelizzola M. methylPipe and compEpiTools: a suite of R packages for the integrative analysis of epigenomics data. BMC Bioinformatics 16, 313 (2015); DOI: 10.1186/s12859-015-0742-6
12. Tonelli C, Amati B, Morelli MJ. p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo: Computational analysis of next-generation sequencing data. Genomics Data 7, 29-31 (2015); DOI:1016/j.gdata.2015.11.006.
13. Marzi M, Ghini F, Cerruti B, De Pretis S, Bonetti P, Giacomelli C, Gorski MM, Kress T, Pellizzola M, Muller H, Amati B, Nicassio F. Degradation dynamics of microRNAs revealed by a novel pulse-chase approach. Genome Res. 26, 554-65 (2016); DOI: 1101/gr.198788.115
14. D'Artista L, Bisso A, Piontini A, Doni, M, Verrecchia A, Kress TR, Morelli MJ, Del Sal G, Amati B*, Campaner S*. Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc. Oncotarget 7, 21786-98 (2016); DOI:18632/oncotarget.7846
15. Kress TR, Pellanda P, Pellegrinet L, Bianchi V, Nicoli P, Doni M, Recordati C, Bianchi S, Rotta L, Capra T, Ravà M, Verrecchia A, Radaelli E, Littlewood TD, Evan GI and Amati B*. Identification of Myc-dependent transcriptional programs in oncogene-addicted liver tumors. Cancer Research 76, 3463-72 (2016); DOI: 1158/0008-5472.CAN-16-0316
16. Bianchi V, Ceol A, Ogier AG, De Pretis S, Galeota E, Kishore K, Bora P, Croci O, Campaner S, Amati B, Morelli MJ and Pelizzola M. Integrated systems for NGS data management and analysis: open issues and available solutions. Genet. 7:75 (2016); DOI:10.3389/fgene.2016.00075
17. Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, Rajkowska K, Gaweda-Walerych K, Ingallina E, Tonelli C, Morelli MJ, Amato A, Eterno V, Zambelli A, Rosato A, Amati B, Wisniewski JR and Del Sal G. Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer. Nature Cell Biology 18, 897-909 (2016); DOI:1038/ncb3380
18. Bagislar S, Sabò A, Kress T, Doni M, Nicoli P, Campaner S, Amati B*. Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis. Oncotarget 7, 66398-415 (2016); DOI: 18632/oncotarget.12012
19. D' Andrea A, Gritti I, Nicoli P, Giorgio M, Doni M, Conti A, Bianchi V, Casoli L, Sabò A, Mironov A, Beznoussenko GV, Amati B*. The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas. Oncotarget 7, 72415-30 (2016); DOI: 10.18632/oncotarget.11719
20. Ravà M, D' Andrea A, Doni M, Kress TR, Ostuni R, Bianchi V, Morelli, MJ, Collino A, Ghisletti S, Nicoli P, Recordati C, Iascone M, Sonzogni A, D'Antiga L, Shukla R, Faulkner GJ, Natoli G, Campaner S, Amati B*. Mutual epithelium-macrophage dependency in liver carcinogenesis mediated by ST18. Hepatology 65, 1708-19 (2017); DOI: 1002/hep.28942
21. Argemí J, Kress TR, Chang HC, Bértolo C, Ferrero R, Moreno H, González-Aparicio M, Hernández-Alcoceba R, Segura V, Uriarte I, Guembe L, Avila MA, Amati B, Prieto J, Aragón T. X-box Binding Protein 1 Regulates Unfolded Protein, Acute-phase, and DNA Damage Responses During Regeneration of Mouse Liver. Gastroenterology 152, 120316 (2017). DOI: 10.1053/j.gastro.2016.12.040
22. Tonelli C, Morelli MJ, Sabò A, Verrecchia A, Rotta L, Capra T, Bianchi S, Campaner S, Amati B*. Genome-wide analysis of p53-regulated transcription in Myc-driven lymphomas. Oncogene 36, 2921-29 (2017); DOI: 10.1038/onc.2016.443
23. Piccolo V, Curina1 A, Genua M, Ghisletti S, Simonatto M, Sabò A, Amati B, Ostuni R, Natoli G. Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross talks. Nature Immunology 18, 530-40 (2017), DOI:10.1038/ni.3710
24. Parodi ACL, Sangalli LM, Vantini S, Amati B, Secchi P, Morelli MJ. FunChIP: an R/Bioconductor package for functional classification of ChIP-seq shapes. Bioinformatics 33, 2570-72 (2017); DOI: 1093/bioinformatics/btx201
25. De Pretis S, Kress TR, Morelli MJ, Sabò A, Locarno C, Verrecchia A, Doni M, Campaner S, Amati B, Pelizzola M. Integrative analysis of RNA Polymerase II and transcriptional dynamics upon MYC activation. Genome Res. 27, 1658-64 (2017); DOI: 1101/gr.226035.117
26. Croci O, De Fazio S, Biagioni F, Donato E, Caganova M, Curti L, Doni M, Sberna S, Aldeghi D, Biancotto C, Verrecchia A, Olivero D, Amati B, Campaner S. Transcriptional integration of mitogenic and mechanical signals by Myc and YAP. Genes & Development 31, 2017-2022 (2017); DOI:10.1101/gad.301184.117
27. Ravà M, D' Andrea A, Nicoli P, Gritti I, Donati G, Doni M, Giorgio M, Amati B*. Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC/BCL2double-hit B cell lymphoma. Science Translational Medicine 10, eaan8723 (2018); DOI: 10.1126/scitranslmed.aan8723
28. Donato E, Biagioni F, Bisso A, Caganova M, Amati B, Campaner S. YAP and TAZ are dispensable for physiological and malignant haematopoiesis. Leukemia online publication March 26 (2018); DOI: 10.1038/s41375-018-0111-3
29. Sabò A, Amati B*. BRD4 and MYC-clarifying transcriptional specificity. Science 360, 713-714 (2018) [perspective]; DOI: 10.1126/science.aat6664
30. Santoro A, Vlachou T, Luzi L, Melloni G, Mazzarella L, D’Elia E, Aobuli X, Pasi CE, Reavie L, Bonetti P, Punzi S, Casoli L, Sabò A, Moroni MC, Dellino GI, Amati B, Nicassio F, Lanfrancone L, Pelicci P53-loss in breast cancer leads to Myc activation, increased cell plasticity and expression of a mitotic signature with unique prognostic value. Cell Reports In press